48 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Cellular immune deficiency ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... Clinical Presentation ... • HLH Labs: ... Treatment: • Corticosteroids ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... age, however the disease ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management
Korsakoff Syndrome
Clinical Findings:
 • Confabulation: Usually initial phase of the disease
 • Anterograde amnesia: Memory impairment
Korsakoff Syndrome ... Clinical Findings ... initial phase of the disease ... presentation of Thiamine deficiency ... Encephalopathy Treatment
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
may cause severe clinical ... due to chronic disease ... Palpitations • Diarrhea ... • Vitamin D deficiency ... hyperparathyroidism Treatment
Campylobacter
Clinical 
 • Fever 
 • Abdominal pain 
 • Diarrhea (bloody stools) 
 • Vomiting
Campylobacter Clinical ... Abdominal pain • Diarrhea ... Guillain-Barré syndrome ... Management ... Antibiotics for severe disease
Risk Factors and Signs of Copper Deficiency
Risk Factors:
 • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Signs of Copper Deficiency ... , Chronic diarrhoea ... , Short bowel syndrome ... dental fixatives, Treatment ... drkeithsiau #Copper #Deficiency
Leptospirosis
Pathogen: Leptospira (interrogans, kirschneri, noguchii)
Risk Factors:
 • Occupational exposure - Farmers, ranchers, trappers, veterinarians
 • Recreational
, vomiting and diarrhea ... Severe pulmonary disease ... Epidemiologic exposure + clinical ... microbiology #diagnosis #treatment ... #management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Clinical triad ... mevalonate kinase deficiency ... #diagnosis #management ... #treatment #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
common in Asia • HLA-B51 ... association • M > F Clinical ... (Clinical Dx). ... Arthritis, AS Treatment ... #diagnosis #management