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differential algorithm management systemic generalized pruritus rheumatology activation classification common cvid disorders eosinophil eosinophilia hemeonc hemolytic hemophagocytic hlh hypogammaglobulinemia immunodeficiency
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... discoloration) • Liver ... #dermatology #Differential ... #Diagnosis #Algorithm ... #causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... • Transfusion reactions ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... deficiency • Liver ... fever • Drug reactions ... #hematology #rheumatology ... #nonpalpable #dermatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... • Cholestatic liver ... renal failure/uremia ... Pruritus #primary #secondary ... #generalized #dermatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Screen for secondary ... allergy, drug reaction ... glucocorticoid treatment ... #Differential #diagnosis ... #hematology #eosinophilia
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential Diagnosis ... hypertension and/or drug treatment ... - Secondary autoimmune ... Megaloblastic anemia-rare ... #causes #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
- Differential Diagnosis ... renal failure/uremia ... #Pruritus #secondary ... #generalized #dermatology ... #Algorithm #causes
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... disease • Liver ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Classified among the secondary ... with leukopenia, anemia ... thrombocytopenia • Liver ... Treatment: • Corticosteroids ... #Management #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... DDX: Rule Out Secondary ... Causes • Anemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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