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rheumatology dermatology arthritis differential management pain sle ana anca antibodies antimda5 antimda5dm antineutrophil antinuclear antinxp2 antinxp2dm approach clues comparison disease
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... Antiphospholipid-antibody ... lesions • Discoid lupus ... erythematosus ... #differential #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... Polymyositis and dermatomyositis ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Pain - Diagnostic ... spondyloarthropathies, lupus ... Like in this case ... #rheumatology # ... approach #workup
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
) Inflammatory joint ... #diagnosis #sle ... #clues #system ... #erythematosus # ... rheumatology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
Periorbital heliotrope (blue-purple ... with edema • Erythematous ... interphalangeal joints ... violaceous macules and erythematous ... dermatology #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Erythematosus ( ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... • Systemic lupus ... erythematosus ( ... (to support a diagnosis ... #diagnosis #testing
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
with edema • Erythematous ... interphalangeal joints ... Muscle atrophy may cause ... levels • NXP-2 antibody ... : • ILD was diagnosed
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