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diagnosis oncology rheumatology antinxp2 causes chronic dermatologic dermatomyositis distribution eosinophil eosinophilia erythematosus gap globulin gpa granulomatosis hemolytic hodgkins leukemia lupus
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
: • Squamous cell ... cell carcinoma ... fungoides (cutaneous T-cell ... : • Sickle Cell ... ulcerative #skinrash #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Hepatomegaly • Skin ... lymphoproliferative disorders ... • Neutropenia, anemia ... #oncology #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... eosinophilia (common ... symptoms (eg, skin ... #Algorithm #Differential ... #diagnosis #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential ... - T Cell ~10% ... - B-Cell ~90% ... #Classification ... pathophysiology #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... Consider RBC membrane disorder ... #workup #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
disease or more commonly ... Maculopapular rash ... reticularis Differential ... syndrome • Giant cell ... Polyangiitis #GPA #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Most common cytopenia ... blood count with differential ... Syndromes #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #hematology #oncology ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Disease Classification ... permanent alopecia Differential ... Angioimmunoblastic T-cell ... Kidney disease common ... : • Chronic B-cell
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... carcinoma • Clear cell ... adenocarcinoma • Non-small-cell ... #diagnosis #management ... dermatology
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