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diagnosis oncology chronic leukemia rheumatology agglutinin causes cold cvid dermatologic disease erythematosus gap globulin gpa granulomatosis hemeonc hodgkins hypogammaglobulinemia immunodeficiency
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Orange or Hep C Clinical ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #oncology #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... - T Cell ~10% ... - B-Cell ~90% ... #Classification ... pathophysiology #Hematology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
: • Squamous cell ... cell carcinoma ... fungoides (cutaneous T-cell ... : • Sickle Cell ... ulcerative #skinrash #dermatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... Transformation to large cell ... lymphoma (Richter ... uw_IMresidency #CLL ... Leukemia #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... Consider RBC membrane disorder ... #Anemia #Differential ... #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
(CLL) - Monoclonal ... malignancies - B-cell ... malignancies -> CLL ... significance (MGUS), CLL ... #anemia #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... - Clinical Presentation ... Workup: • Full ... #hematology #oncology ... #management
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
disease or more commonly ... Rarely dominate the clinical ... reticularis Differential ... syndrome • Giant cell ... Polyangiitis #GPA #dermatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to impaired B-cell ... to 8 years Clinical ... anemia) • Systemic ... hypogammaglobulinemia #immunology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Most common cytopenia ... blood count with differential ... Syndromes #diagnosis #hematology
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