13 results
Pathogenesis of Nonalcoholic Steatohepatitis. Various factors, including inflammation, hyperinsulinemia or insulin resistance, and altered lipid homeostasis,
induce metabolic stress ... , oxidative stress ... reticulum–related stress ... #Pathophysiology ... NonAlcoholicFattyLiverDisease #NEJM
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
peripheral-blood smear ... revealed 25% plasma cells ... PlasmaCell #Leukemia #Smear ... #NEJM
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
convoluted tubule cells ... , principal cells ... and intercalated cells ... #Pathophysiology ... NephronRemodeling #NEJM
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
peripheral-blood smear ... acanthocytes (or spur cells ... Spur cells acquire ... #NEJM #clinical ... peripheral #blood #smear
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
adsorption onto cancer cells ... disorders • Shear ... stress-induced
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
spleen in which red cells ... between endothelial cells ... #Pathophysiology ... HereditarySpherocytosis #NEJM
The Effect of Zinc on the Enteral Absorption of Copper. Panel A shows how copper (Cu)
of intestinal cells ... #Pathophysiology ... CopperAbsorption #NEJM
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... • Peripheral smear ... Schistocytes, helmet cells
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
virus or Group A Strep ... various inflammatory cells ... HenochScholeinPurpura #Pathophysiology
Immunosuppressive Strategies for the Prevention or Treatment of Acute GVHD. Panel A shows several classic immunosuppressive
of activated T cells ... #Pathophysiology ... Immunosuppression #NEJM