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diagnosis differential hyperkalemia high nephrology pharmacology antiarrhythmics cardiology classes classification hypokalemia antiphospholipid druginduced hematology hypercoagulable low lymphadenopathy phases syndrome vaughan
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
inhibition (NSAIDs, Beta-Blockers ... Sodium-channel blockers ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... cells: Insulin, Beta-Agonist ... #causes #potassium ... #low #pathophysiology
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
duration CLASS 2 - Beta ... repolarization CLASS 3 - Potassium ... alpha & beta adrenergic ... Classification #Classes ... #pathophysiology
Lymphadenopathy - Differential Diagnosis Algorithm Localized: • Cervical: EBV, CMV, HIV, Toxo, TB, Lymphoma, Head /
Differential Diagnosis Algorithm ... Sarcoidosis • Medications ... : Allopurinol, Beta-Blockers ... Differential #Diagnosis #Algorithm ... #Causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• Recent IV potassium ... • Beta blockers ... Medications 2. ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• Recent IV potassium ... • Beta blockers ... Medications 2. ... differential #diagnosis #causes ... #potassium #high
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
duration CLASS 2 - Beta ... repolarization CLASS 3 - Potassium ... alpha & beta adrenergic ... Classification #Classes ... #pathophysiology
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... hyperosmolality - Medications ... : beta blockers, ... Differential #Diagnosis #Causes ... #potassium #high
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome (APLS ... Hypercoagulable Workup Algorithm ... INDICATIONS FOR ... maternal chromosomal causes ... IgG and IgM • Beta
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic algorithm ... correcting serum potassium ... Other medications ... angiotensin receptor blockers ... continued in most cases
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