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diagnosis differential causes hyperkalemia hypokalemia nephrology pathophysiology pharmacology antiarrhythmics cardiology classes management treatment acidosis antiarrhythmic criticalcare elevation foamed high intercellularshift
Antiarrhythmic Medications - Vaughan Williams Classification - Summary Table Class I agents - Sodium Channel Blockers⠀ Class II
Vaughan Williams Classification ... this class are beta ... blockers.⠀ Class ... III agents - Potassium ... #Medications #Classification
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Vaughan Williams Classification ... duration CLASS 2 - Beta ... repolarization CLASS 3 - Potassium ... alpha & beta adrenergic ... #Pharmacology #Classification
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Vaughan Williams Classification ... duration CLASS 2 - Beta ... repolarization CLASS 3 - Potassium ... alpha & beta adrenergic ... #Pharmacology #Classification
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Differential Diagnosis Algorithm ... cells: Insulin, Beta-Agonist ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Differential Diagnosis Algorithm ... Alkalosis • ↑ beta ... vomiting) • Low ... #nephrology #low ... #potassium
The Diagnostic Approach to Hyperkalemia Drugs - Amiloride - Spironolactone - Triamterene - Trimethoprim - Pentamidine -
deficiency - Heparin/ LMW ... Ketoconazole Low ... - NSAlDs - Beta-Blockers ... #Hyperkalemia #Algorithm
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Hyperkalemia Treatment Algorithm ... bradycardia, AV blocks ... Combo of insulin + beta-agonist ... glucose <100 • Beta-agonist ... treatment Remove potassium
Causes of Hyperkalemia - Reduced Excretion - Differential Diagnosis Algorithm Reduced flow through distal nephron - TTKG
Differential Diagnosis Algorithm ... < 20 meq/L • Low ... Aldosterone • ENaC blockers ... nephropathy • Beta ... Differential #Diagnosis #Algorithm
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
fatty acids for beta-oxidation ... also converted to beta ... both conditions, low ... provided the starting potassium ... #differential #algorithm
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Beta-Adrenergic ... inhibitors, ß-blockers ... Drug-associated: heparin, low-molecular-weight ... Diagnosis #High #Potassium ... #Classification
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