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Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... US - Dilated Bile ... Duct Stone • Biliary ... Differential #Diagnosis #Algorithm ... #Causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Intestine - Other causes ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Extrahepatic - Biliary ... - Obstruction: Biliary ... differential #diagnosis #algorithm
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... cholestasis, and some cases ... miscellaneous causes ... external pressure on bile ... #differential #causes
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Sequestrants → ↓ Hepatic Bile ... Pool → ↑ Hepatic Bile ... Plasma LDL-C #biliary
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... of intralobular bile ... ducts causes cholestasis ... No extrahepatic biliary ... malignancy #Primary #Biliary
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... • US - Normal Bile ... • US - Dilated Bile ... - CBD stone, Biliary ... Transaminitis #Algorithm
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
the liver ALP - Biliary ... tree or bile flow ... abnormality vs bone Bili
Common Bile Duct Biliary Stone removal on ERCP Dr. Joaquín Berrueta Mezzera @DrJBerrueta #Biliary #Stone #removal #extraction #ERCP
Common Bile Duct ... Biliary Stone removal ... DrJBerrueta #Biliary
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 Diseases of the Biliary Tract Asymptomatic gallstones - Asymptomatic Symptomatic gallstones - Biliary pain Cholesterolosis of gallbladder - Usually
Diseases of the Biliary ... Adenomyomatosis - May cause ... biliary pain Porcelain ... quadrant pain, nausea ... quadrant pain, nausea
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