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diagnosis hepatology differential clinical algorithm management causes disease lfts dermatology gastroenterology hematology injury laboratory ucsdh acute nejm pathophysiology syndrome transaminitis
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... • Conjugated Bilirubin ... • Unconjugated Bilirubin ... LouLectures #Bilirubin ... Pathophysiology #hepatology #Liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Check Acute viral hepatitis ... Check Acute viral hepatitis ... week • Direct bilirubin ... Chronic viral hepatitis ... Elevation: • Bilirubin
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... week • Direct bilirubin ... Chronic viral hepatitis ... Elevation: • Bilirubin ... #injury #hepatitis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin ... hepatology #obstetrics #hepatitis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Phosphatase and Bilirubin ... initial insult Bilirubin ... transports conjugated bilirubin ... ASTALT #AlkPhos #Bilirubin
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
Liver Function Tests ... transpeptidase (GGT) - Bilirubin ... Prothrombin #Liver
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
diagnosis of Alcoholic Hepatitis ... • Serum total bilirubin ... Possible ischemic hepatitis ... ) or metabolic liver ... Possible drug-induced liver
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
of Severe Acute Liver ... Injury - Ichemic hepatitis ... - Drug-Induced liver ... injury - Viral Hepatitis ... - Autoimmune hepatitis
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... nucleotidase - Liver ... in bone Total bilirubin ... TBili) Direct bilirubin ... Indirect bilirubin
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
of Autoimmune Hepatitis ... - Serum total bilirubin ... Possible ischemic hepatitis ... ) or metabolic liver ... Possible drug-induced liver
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