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diagnosis management clinical algorithm dermatology differential rheumatology hepatology pharmacology photo causes physicalexam video skinrash table ucsdh skin syndrome gastroenterology medications
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
↑ AST ↑ ALT ↑ bilirubin ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... • Conjugated Bilirubin ... • Unconjugated Bilirubin ... LouLectures #Bilirubin ... Pathophysiology #hepatology
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
Metabolism of Bilirubin ... → Unconjugated Bilirubin ... "indirect bilirubin ... and "indirect" bilirubin ... pathophysiology #hepatology
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Unconjugated bilirubin ... workup #diagnosis #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
haptoglobin ↑ indirect bilirubin ... diagnosis #management #treatment ... #rheumatology
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
suspect underlying hematologic ... Diagnosis and Treatment ... Syndrome #HES #Hematology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... initial insult Bilirubin ... transports conjugated bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
birth with serum bilirubin ... associated with bilirubin ... in conjugated bilirubin ... in conjugated bilirubin ... #hepatology #diagnosis
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Increased Serum bilirubin ... Causes #Workup #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Non malignant hematologic ... effect following treatment ... states • Non-hematologic ... Algorithm #Causes #Hematology
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