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nephrology diagnosis pharmacology alkalosis differential management metabolic table thiazide algorithm cardiology causes chf chloride classes conversion dosing electrolytes halflife hyperkalemia
Pharmacology of diuretics Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Acetazolamide, Loop ... Half-Life, Onset, Bioavailability ... , Absorption # ... #Comparison #Table ... HalfLife #Dosing #Loop
Diuretic Electrolyte Excretion Effects Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid - Thiazide Type
Excretion Effects ... Acid - Thiazide Type ... - Loop - Aldosterone ... #electrolytes #effects ... #pharmacology #comparison
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
Thiazide diuretics ... channel (indirect effect ... ) Loop diuretics ... channel (direct effect ... ) #NaCI reabsorption
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... • Inhibit Na+ reabsorption ... as no effect on ... sodium reabsorption ... nephrology #conversion #loop
Causes of Metabolic Alkalosis: Differential Diagnosis ECF volume contracted: urine chloride concentration <20 meq/L • Gastric alkalosis:
• Thiazide or loop ... diuretics after ... effect has dissipated ... syndrome (11-ß HSD type ... in loop of Henle
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Aldosterone, RTA Type ... Ureterojejunostomy (reabsorption ... (IV loop diuretic ... acetazolamide) - IV loop ... diuretic (lasix
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Remote use of loop ... or thiazide diuretics ... pressure: Active diuretic ... mineralocorticoid-like effect ... acidosis-induced decreased reabsorption
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