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diagnosis hematology causes anemia algorithm rheumatology oncology agglutinin approach atlas basics cold cryofibrinogenemia disease erythematosus extravascular hemolysis hodgkins infections infectiousdiseases
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... usually IgM) (e.g. primary ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Reticulocytosis • Primary ... • Acute Bleed ... • Hemolysis ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... Loss • Acute Bleed ... Smear • Chronic Bleed ... • RBC Membrane Disorder ... Non-lmmune #Anemia #Classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... purple, hemorrhagic skin ... /Quantity: • Primary ... DIC/TTP/HUS - Hemolytic ... #nonpalpable #dermatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... Post-splenectomy Primary ... Diagnosis #Causes #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... 80-100 fL) • Bleeding ... • Hemolysis ... #Anemia #MCV #Classification ... #Differential #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... lymphoproliferative disorder ... infection, autoimmune disorder ... younger pts) Differential ... #anemia #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... - History of bleeding ... epistaxis, gingival bleeding ... unclear, or if a primary ... #Differential #
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
Lesions Primary ... bruise') is where bleeding ... a generalized disorder ... #Diagnosis #Dermatology ... #Skin #Primary
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... Abnormalities in primary ... Vasculitis - Collagen disorders ... cryoglobulins • Skin ... Algorithm #Causes #dermatology
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