26 results
Stroke and bleeding risk stratification with the CHADS2-VASc and HAS-BLED schemas

#Diagnosis #Hematology #CHADS2 #CHADS2VASc #HASBLED #Comparison
Stroke and bleeding ... CHADS2-VASc and HAS-BLED ... #Diagnosis #Hematology ... #Risk #Stroke #Bleed
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Beta-Blockers in Cirrhosis
 • Pathophysiology
 • Indications:  Prevention of decompensation, Prevention of first variceal bleeding,
in Cirrhosis • Pathophysiology ... first variceal bleeding ... Prevention of variceal rebleeding ... BetaBlockers #Cirrhosis #hepatology ... #management #pharmacology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
CHA2DS2VASc vs HAS-BLED ... stroke risk and bleed ... S Stroke 1 B Bleeding ... #Risk #Stroke #Bleed ... AFib #Diagnosis #Hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
Bleeding risk calculators ... - HAS-BLED (atrial ... with very high bleeding ... based on high bleeding ... Anticoagulation #Factors #Hematology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Medications #Pharmacology ... #Pathophysiology ... Mechanisms #DOAC #Hematology
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Thrombosis and Bleeding ... #Thrombosis #Bleeding ... Clot #Cirrhosis #Pathophysiology ... #Hepatology #Liver
Stress Ulcer Prophylaxis

Stress ulcerations are common in ICU patients and may lead to hemorrhage if not
prevention of bleeding ... ulcer-related bleeding ... (nosocomial GI bleeding ... hospitalization) • Pathophysiology ... #criticalcare #pharmacology
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
#Lactulose #pharmacology ... mechanism #ammonia #hepatology ... #pathophysiology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
and procedural bleeding ... with a very low bleeding ... Therapy • Low Bleed-Risk ... postoperative • High Bleed-Risk ... Management #Treatment #pharmacology
Aortoenteric Fistula - Diagnosis and Management Summary
Epidemiology:
• Uncommon but life-threatening
• Most common site of bowel connection
Classic triad: Bleeding ... may be herald bleed ... Typical "herald bleed ... Pathophysiology: ... patients with massive bleed