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diagnosis differential rheumatology clinical monkeypox vasculitis dermatology management photo anca mpv mpx ophthalmology algorithm eye lesions lupus redeye causes classification
Monkeypox What? Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus Viral zoonotic disease that is
with someone with Mpox ... inguinal region • Mpox-related ... with confirmed mpox ... Conjunctivitis • Blepharitis ... #Monkeypox #MPOX
Blepharitis is one of the most common disorders of the eye and is often the underlying
Blepharitis is one ... #blepharitis #scurf
Painless Red Eye - Differential Diagnosis • Subconjunctival Hemorrhate • Episcleritis • Blepharitis • Dry
Episcleritis • Blepharitis
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with MPO ... polyangiitis - MPO ... polyangiitis - MPO ... Renal-limited - MPO ... #CANCA #PANCA #MPO
Atraumatic Red Eye - Differential Diagnosis Algorithm Lids / Orbit / Lacrimal System: • Blepharitis • Stye
Lacrimal System: • Blepharitis
Red Eye - Differential Diagnosis Lids: • Stye (a.k.a. hordeolum) • Chalazion • Blepharitis • Periorbital cellulitis Conjunctiva
• Chalazion • Blepharitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO ... PR3 (80-90%) > MPO ... involvement - PR3>MPO ... Churg-Strauss) - MPO ... Anti-GBM disease - MPO
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
myeloperoxidase (MPO-ANCA ... present in >90%, MPO ... Granulomas - MPO ... (10-40% ANCA +MPO ... 100 % Commonly MPO-ANCA
Red Eye - Differential Diagnosis Framework What? Redness in the eye can be caused by many conditions and
most common) • Blepharitis ... • Chalazion • Blepharitis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
MPA > eGPA • MPO-ANCA
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