ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due to the lack of immune deposits. Includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulonatosis with polyangiitis (EGPA). - C-ANCA pattern (usually associated with PR3+ antibody) - P-ANCA pattern (usually associated with MPO+ antibody) Granulomatosis with polyangiitis - 80-90% PR3+ Granulomatosis with polyangiitis without renal involvement - PR3>MPO Microscopic polyangiitis - MPO>PR3 Eosinophilic granulomatosis with polyangiitis - MPO>PR3 Renal-limited - MPO+ about 75-90%, rarely PR3 Anti-GBM disease - MPO>PR3 Levamisole-induced vasculitis - MPO+ almost 100%, PR3+ 50%, frequently double+ Hydralazine-induced ANCA vasculitis - MPO > PR3 Dr. Ann Marie Kumfer @AnnKumfer #ANCA #Associated #Vasculitis #CANCA #PANCA #MPO #PR3 #Diagnosis #Rheumatology
