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diagnosis hematology differential monoclonal apml capillary clinical differentiation gammopathy leak mgus paraproteinemias significance sjogrens timeline treatment
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
capillary leak syndrome ... (Clarkson's) ... • Schnitzler syndrome ... Ig deposition disease ... #oncology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Clarkson’s Disease ... filling +++ (risk of pulmonary ... Breillat #Clarksons ... #diagnosis #management ... timeline #treatment #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... hemangiomata, clubbing Clarkson ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... : • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... #Rheumatology # ... Diagnosis #Management
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