13 results
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Diagnostic Algorithm Pathophysiology ... - Pathophysiology ... instability - New-onset ... #Diagnosis #Dermatology ... Targetoid #Algorithm #Differential
Severe Drug Rashes - Comparison - DRESS | SJS/TEN | AGEP | Erythroderma

DRESS 
 - Onset:
Drug Rashes - Comparison ... DRESS - Onset ... #Drug #Rashes #Comparison ... #Erythroderma #Dermatology ... #Emergency #Differential
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
body water in comparison ... total body sodium content ... osmolality helps to differentiate ... ADH release is also ... Circulating ADH
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Dermatomyositis • Onset ... Polymyositis • Onset ... Inflammatory #Myopathies #differential ... #diagnosis #comparison ... #rheumatology #
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... severe • Rare: DAH ... initiation • Differential ... (sepsis), PE, DAH ... diagnosis #management #hematology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Pregnancy (ICP) • Onset ... Platelets) • Onset ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis • Slow onset ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... >2400 Ul/ml, ↑ LDH ... SLE+++, Adult-onset ... treatment #summary #rheumatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
elevation and clinical context ... normalised ratio; LDH ... Abnormal #Algorithm #Hepatology ... Liver #Enzymes #Differential
General Approach to Anemia - Differential Diagnosis Framework
1) Check reticulocyte count to determine if hypo/hyper-proliferative
2) Exclude
Approach to Anemia - Differential ... hyper-proliferative (LDH ... MCV & clinical context ... uw_IMresidency #anemia #differential ... #diagnosis #hematology