10 results
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... -12, or folate deficiency ... Content • RBC Transfusions ... blood loss • Hemolytic ... #Decrease #Diagnosis
Folate Deficiency - Causes of Decreased Folic Acid
↓ Intake: Diet, Age, Alcohol
↑ Demand: Pregnancy, Infancy, Hemolysis,
Folate Deficiency ... - Causes of Decreased ... Pregnancy, Infancy, Hemolysis ... drkeithsiau #Folate #Deficiency ... #FolicAcid #differential
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... products contain potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Recent IV potassium ... paralysis - Insulin deficiency ... Mineralocorticoid deficiency ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Recent IV potassium ... paralysis - Insulin deficiency ... Mineralocorticoid deficiency ... differential #diagnosis #causes ... #potassium #high
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... products contain potassium ... more likely to cause
Etiologies of Folate Deficiency
 • Decreased dietary intake - uncommon in this era
 • Increased requirements
• Decreased dietary ... pregnant have hemolytic ... folate that can cause ... anticonvulsants lead to increase ... #FolicAcid #differential
Causes of Hyperkalemia
Pseudohyperkalemia
 - Tourniquet use
 - Hemolysis (in vitro)
 - Leukocytosis
 - Thrombocytosis
Intra- to extracellular
Causes of Hyperkalemia ... Tourniquet use - Hemolysis ... drugs - Transfusion ... aged blood - Hemolysis ... tissue necrosis Decreased
Causes of Hyperkalemia - Differential Diagnosis Framework
 • Cellular Shift:
   - Exercise
Causes of Hyperkalemia ... - Insulin deficiency ... Crush injury, Hemolysis ... Differential #Diagnosis #Causes ... #potassium #high
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Causes of Hyperkalemia ... leukocytosis, in vitro hemolysis ... Decreased distal ... aldosterone synthase deficiency ... Diagnosis #High #Potassium