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diagnosis differential anemia blood hemolysis management product classification congenital dermatology extravascular gastroenterology hepatology hyperbilirubinemia inherited intravascular nonpalpable palpable purpura rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... reaction, Paroxysmal ... reaction • Intrinsic ... Extravascular #Causes ... differential #diagnosis #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... Transfusion Reaction ... Transfusion Reaction ... Transfusion Reaction ... diagnosis #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Transfusion Reaction ... Transfusion Reaction ... Transfusion Reaction ... Causes purpura & ... diagnosis #management #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... AIHA, Cold AIHA, Transfusion ... reactions, Drug-associated ... - Unconjugated Bilirubin ... Differential #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... prosthetic valve • Transfusion ... reactions ex. ... udaygulati #Hemolytic ... classification #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... in most cases; ... Platelet count - Decreased ... anemia Indirect bilirubin ... Diagnosis #Workup #Hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... without evidence of hemolysis ... and stress may cause ... patients have an increase ... #hepatology #diagnosis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Fragility: • Decreased ... fever • Drug reactions ... Differential #Diagnosis #hematology ... #rheumatology #
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