13 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Post-strep GN, Lupus ... Idiopathic • Normal ... Complement: IgA ... differential #diagnosis #algorithm ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... - CRP: Usually normal ... 80% - Low complement ... management of SLE • Evolution ... Management #Summary #rheumatology
Evaluation abnormal liver tests in pregnancy
- Cholestatic Pattern
- Hepatocellular Pattern

#LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal ... obgyn #obstetrics #hepatology ... #differential #algorithm
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... 90% - Low complement ... - CRP: Usually normal ... 80% - Low complement ... comparison #table #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... Drug-induced AIHA - Abnormal ... perfringens - Complement-Mediated ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor and lupus ... Willebrand syndrome • Lupus ... administration, evaluation ... The appropriate evaluations ... Differential #Diagnosis #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... sedimentation rate + Normal ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... RNP antibodies, Complement
Complement Deficiency Testing Algorithm
 • Normal CH50 and AH50 AND High suspicion for complement deficiency
 •
Complement Deficiency ... Testing Algorithm ... suspicion for complement ... Deficiency #Testing #Algorithm ... #hematology #diagnosis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... indicate the initial evaluation ... history alongside evaluation ... #Algorithm #Hepatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Differential Diagnosis Algorithm ... Thrombocytopenia - Abnormal ... deficiency - Abnormal ... Autoimmune Vasculitis (lupus ... #Causes #dermatology