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diagnosis differential hematology lupus nephrology rheumatology causes management nephritis systemic erythematosus glomerular glomerulonephritis laboratory pancytopenia pediatrics peds anemia arthritis biopsy
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Effect of Selected Diseases ... on Complement Levels ... - C3, C4 • SLE ... C3 ↓ C4 ↓↓ • Cryo ... ThePeanutKidney #Complement
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... ulcers, Lupus nephritis ... • Immunologic Workup ... 80% - Low complement ... Evolution: Chronic disease
Algorithm for the Treatment of Membranous Lupus Nephritis Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the ... treat non-renal SLE ... for worsening disease ... treat extra-renal SLE ... #Algorithm #Treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... RNP antibodies, Complement ... SSA can rule in SLE ... papillomavirus #SLE
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... 90% - Low complement ... ulcers, Lupus nephritis ... • Immunologic Workup ... Evolution: Chronic disease
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... for glomerular disease ... or alternative complement ... of glomerular disease ... #workup #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Post-strep GN, Lupus Nephritis ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... differential #diagnosis #algorithm
Hyperthyroidism (low TSH, High T4/T3) - Diagnostic Algorithm Radioactive iodine scan – get if concern for nodular
) - Diagnostic Algorithm ... affects diagnostic workup ... management options (see ... Hyperthyroid #Diagnosis #Algorithm ... #Workup #Endocrinology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... ): SS, SC, SE, Sβ ... Differential #Diagnosis #Algorithm ... #workup #hematology ... #testing
Diagnostic algorithm for a child or adolescent with suspected pulmonary hypertension. CHD, congenital heart disease; CPET,
Diagnostic algorithm ... congenital heart disease ... cardiopulmonary exercise testing ... #Hypertension #Workup ... #Algorithm
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