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diagnosis rheumatology differential management comparison druginduced erythematosus table types vasculitis allergy criteria cryoglobulinemia cryoglobulins dil eularacr hematology high hyperkalemia hypersensitivity
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... Positive in 60-80% of cases ... 80% - Low complement ... #lupus #Systemic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... • Immunologic Workup ... months to years) Systemic ... • Immunologic Workup ... Positive in 60-80% of cases
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... anticoagulant • Complement ... #Criteria #SLE ... #Systemic #Lupus
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... they activate complement ... glomerulonephritis, Systemic ... lupus erythematosus ... allergy #table #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... lupus erythematosus ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... lupus erythematosus ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... frequently affected systems ... some time, let’s see ... about secondary causes ... #workup #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... 90% - Low complement ... Discontinuation of causal
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... lupus erythematosus ... (SLE), sickle cell ... High #Potassium #Classification ... #Causes
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