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diagnosis rheumatology differential types allergy causes hypersensitivity management nephritis nephrology reactions systemic table vasculitis alopecia classes comparison criteria cryoglobulinemia cryoglobulins
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Skin Disease Classification ... pneumonitis • Diffuse ... enteropathy, and diffuse
Lupus Nephritis Primer Class I - Minimal Mesangial Class II - Mesangial Proliferative Class Ill - Focal Proliferative Class IV
Lupus Nephritis ... Proliferative Class Ill - Focal ... Proliferative Class IV - Diffuse ... #Nephritis #SLE ... #Classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Erythematosus ... anticoagulant • Complement ... #Criteria #SLE ... #Erythematosus
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
Diagnosis Algorithm ... Irreversible-biopsy required • Lupus ... erythematosus ... • Discoid lupus ... erythematosus
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... by 12 months Classification ... • Class Ill - Focal ... • Class IV - Diffuse ... glomeruli) Diffuse
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... Complement activation ... , and systemic lupus ... erythematosus ... Hypersensitivity #Types #Classification
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
they activate complement ... chain causing local ... glomerulonephritis, Systemic lupus ... erythematosus Type ... allergy #table #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... (e.g. systemic lupus ... erythematosus ( ... SLE), rheumatoid ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
such as systemic lupus ... erythematosus, ... against MPO • Complement ... vasculitis, and SLE ... #rheumatology #classification
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
diseases: syßtemic lupus ... erythematosus ( ... SLE), sickle cell ... Tubulointerstitial diseases: SLE ... High #Potassium #Classification
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