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diagnosis differential rheumatology nephrology pulmonary vasculitis acute aki causes champs classification erythematosus hematology hypocomplementemia kidneyinjury low mimics mnemonic progressive rapidly
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... staining): • Low Complement ... Post-strep GN, Lupus ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... S - Systemic Lupus ... Erythematosus (total 50, renal ... Hypocomplementemia #Low #Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Diagnosis Framework Diffuse ... rapidly progressive glomerulonephritis ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Definition: Diffuse ... alveolar hemorrhage + Glomerulonephritis ... Complex: Systemic lupus ... anti-CCP • CXR (diffuse
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Differential Diagnosis Algorithm ... at least 50% Renal ... Rapidly Progressive Glomerulonephritis ... IgA, post-strep, lupus ... Sjögren) Post-Renal
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... • Urinalysis (Renal
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... pneumonitis • Diffuse ... enteropathy, and diffuse ... APLA/LAC: • Renal ... RNP antibodies, Complement
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