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diagnosis rheumatology differential cryoglobulinemia cryoglobulins disorders erythematosus gammopathy glomerulonephritis igg4 lymphomas lymphoproliferative management mgrs monoclonal nonhodgkin pathophysiology rapidly renal rpgn
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... Post-strep GN, Lupus ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... pneumonitis • Diffuse ... enteropathy, and diffuse
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement ... #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 complement ... (e.g. systemic lupus ... diagnosis #types #classification ... #rheumatology # ... vasculitis
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... system (node) with progression ... lymphadenopathy more diffuse ... Lymphoproliferative #Disorders #Classification ... pathophysiology #Hematology
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
inflammation -> progressive ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification ... Diagnosis #Management #Rheumatology
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
meet criteria for hematologic ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis ... function and prevent progression
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