5 results
diagnosis differential rheumatology vasculitis classification erythematosus glomerulonephritis mimics myopathies myopathy pulmonary rapidly renal rpgn sle syndromes systemic vasculitides
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Polymyositis • Progressive ... Dermatomyositis • Progressive ... Myopathy • Diffuse ... uncommon 5-15% of lupus ... differential #diagnosis #comparison
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Diagnosis Framework Diffuse ... hemorrhage + rapidly progressive ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement ... , Inflammatory Myositis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... staining): • Low Complement ... Post-strep GN, Lupus ... RPGN #Rapidly #Progressive ... differential #diagnosis #algorithm
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... pneumonitis • Diffuse ... enteropathy, and diffuse ... • Transverse Myelitis ... RNP antibodies, Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... inflammation Others: • Lupus ... Conjunctivitis, mucositis ... such as systemic lupus ... against MPO • Complement
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