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diagnosis differential renal rheumatology management syndromes causes classification erythematosus glomerulonephritis hemoptysis hypoxemia hypoxia massive mimics nephrology progressive prs rapid rpgn
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... Post-strep GN, Lupus ... With associated pulmonary ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Diagnosis Framework Diffuse ... alveolar hemorrhage + rapidly ... anti-GBM) 10%: - Low Complement ... - Normal Complement
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Differential Diagnosis Algorithm ... • Bronchitis Diffuse ... Vasculitis Infection ... Vasculitis • ... Lupus Erythematosus
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Definition: Diffuse ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... Complex: Systemic lupus ... anti-CCP • CXR (diffuse
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
, proteinuria, rapidly ... progressing GN • New pulmonary ... inflammation Others: • Lupus ... such as systemic lupus ... against MPO • Complement
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... ANCA-associated vasculitis ... pneumonitis • Diffuse ... enteropathy, and diffuse ... RNP antibodies, Complement
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... palpable purpura 2/2 vasculitis ... capillaritis leading to diffuse ... hemorrhage (DAH) • Diffuse ... proteinuria • Path: rapidly
Hypoxemia / Hypoxia - Rapid Response Management Algorithm Stridor - Upper airway pathology: • Anaphylaxis • Foreign
Hypoxemia / Hypoxia - Rapid ... Response Management Algorithm ... pathology: • Blood: diffuse ... pneumonia • Water: pulmonary ... #rapid #pulmonary
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