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diagnosis rheumatology erythematosus systemic allergy c3 criteria cryoglobulinemia cryoglobulins differential eularacr hypersensitivity levels reactions table vasculitis
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... • SLE C3 ↓ C4 ... ↓↓ • MCGN type ... • Cryo C3 ↓ C4 ↓ ... ThePeanutKidney #Complement
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... anticoagulant • Complement ... Low C3 or low C4 ... Low C3 and low C4 ... #Criteria #SLE
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... , and systemic lupus ... #Classification ... #Pathophysiology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Low serum C4 ... complement level ... (e.g. systemic lupus ... erythematosus (SLE ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Kikuchi disease • Type-I ... levels (C3 and C4 ... activity • C3 C4
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