14 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Post-strep GN, Lupus Nephritis ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm
Physical:
• Pressure
• Trauma
• Radiation
Vascular:
• Arterial
Skin Ulcers of the ... Differential Diagnosis Algorithm ... insufficiency • Vasculitis ... Lower #Legs #Feet #Ulcers ... #causes
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... periumbilical region), nausea ... 10-50%) - HTN, nephrotic ... /nephritic syndrome
Genital Ulcers - Atypical causes of genital ulcers that can be difficult to diagnose & manage.
Genital Ulcers - ... Atypical causes ... non-sexually acquired, necrotic ... juvenile gangrenous vasculitis ... #Atypical #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... tract, and often causes ... livedo reticularis, ulcers ... genital aphthous ulcers ... against MPO • Complement
Skin Ulcers by Etiology - Differential Diagnosis Algorithm
Physical:
 • Trauma
 • Pressure
 • Radiation
Vascular:
 • Arterial
Skin Ulcers by Etiology ... Differential Diagnosis Algorithm ... insufficiency • Vasculitis ... Cryptococcosis #Ulcers ... #causes
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Purpura - Skin ulcers ... Cryoglobulins Cause ... • Low serum C4 complement ... • Vasculitis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Alopecia, oral ulcers ... , Lupus nephritis ... Positive in 60-80% of cases ... 80% - Low complement
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... effusion), mouth (ulcers ... Nephrocalcinosis causes ... #Algorithm #differential ... #proteinuria #nephrotic
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
or alternative complement ... infections are common causes ... for ANCA-related vasculitis ... glomerulonephritis #nephrotic ... #nephritic #nephrology