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diagnosis differential rheumatology signs symptoms classification dermatology skinrash ulcerative complications cryoglobulinemia cryoglobulins extraarticular feet glomerulonephritis henochscholeinpurpura hsp iga legs lower
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low Complement ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm Physical: • Pressure • Trauma • Radiation Vascular: • Arterial
Skin Ulcers of the ... Differential Diagnosis Algorithm ... insufficiency • Vasculitis ... Lower #Legs #Feet #Ulcers ... #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... tract, and often causes ... livedo reticularis, ulcers ... genital aphthous ulcers ... against MPO • Complement
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Skin Ulcers by Etiology ... Differential Diagnosis Algorithm ... insufficiency • Vasculitis ... Cryptococcosis #Ulcers ... #causes
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Purpura - Skin ulcers ... Cryoglobulins Cause ... • Low serum C4 complement ... • Vasculitis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
IgA Vasculitis – ... Activation of complement ... periumbilical region), nausea ... #HSP #IgA #Vasculitis ... HenochScholeinPurpura #Pathophysiology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... esp legs) -> Leg Ulcers ... inflammation tends to cause ... RheumatoidArthritis #RA #pathophysiology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... > Mouth, Nasal Ulcers ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology
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