10 results
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... - Skin, glomeruli ... : - Kidneys: glomerular ... against MPO • Complement ... differential #diagnosis
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
symptomatology Differential ... ANCA-positive vasculitis ... sclerosis • Anti-Glomerular ... Disease-specific testing ... Renal #Syndrome #differential
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... evaluated for glomerular ... or alternative complement ... for ANCA-related vasculitis ... #testing #workup
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria - Differential ... Diagnosis Algorithm ... present on repeat testing ... including overnight testing ... • Drugs Glomerular
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis ... #differential # ... diagnosis #algorithm
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Vitamin C • Glomerular ... : Drug induced vasculitis ... #KidneyInjury #differential ... #diagnosis #algorithm
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... evaluated for glomerular ... or alternative complement ... for ANCA-related vasculitis ... diagnosis #initial #testing
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... Diagnosis Algorithm ... cardiac valve, vasculitis ... #Diagnosis #Algorithm ... workup #hematology #testing
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Positive Coombs testing ... post infectious setting ... younger pts) Differential ... temperatures by fixing complement
HSCT related renal disease - AKI and CKD
Acute Kidney Injury: Acute GvHD 2-4, Pre renal state,
Kidney Disease: • Glomerular ... body irradiation, Complement ... #disease #AKI #differential ... #diagnosis #algorithm