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diagnosis differential rheumatology renal anca cryoglobulinemia cryoglobulins ddxof gammopathy igg4 large management medium mgrs mimics monoclonal pulmonary rapidly rheum rpgn
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive ... staining): • Low Complement ... RPGN #Rapidly #Progressive ... #Vasculitis #differential ... #diagnosis #algorithm
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... #Diagnosis #IM ... #Rheum #Vasculitis ... #Vessel #Size #Classification ... #Differential #Algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
hemorrhage + rapidly progressive ... glomerulonephritis ... ANCA Associated Vasculitis ... anti-GBM) 10%: - Low Complement ... - Normal Complement
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... - Necrotizing glomerulonephritis ... • Glomerulonephritis ... against MPO • Complement ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... • Low serum C4 complement ... • IgA vasculitis ... • Vasculitis ... diagnosis #types #classification
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
inflammation -> progressive ... aortitis, mimics vasculitis ... - ↑ IgE, ↓ complement ... • Classification
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis ... function and prevent progression
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