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differential oncology rheumatology cardiology chronic infectiousdiseases mds myelodysplastic acidosis activation algorithm cll cvid dermatology elevation erythematosus fatigue hepatopulmonary hodgkins hypogammaglobulinemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #hematology #diagnosis ... #management
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... Associated - SLE ... • Bacterial endocarditis ... #hematology #rheumatology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
• Anemia • ... Malignancy Infectious ... • Endocarditis ... Arthritis • SLE ... Disease Neurologic
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Infant/child: - Infection-common ... Megaloblastic anemia-rare ... patients - Infections-common ... white blood cell aplasia ... #causes #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Autoimmune (SLE ... Cerebral > Splenic, pulmonary ... Septic Emboli Cause ... Leukocytosis, anemia ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... • Anemia • Aplastic ... Myeloproliferative Disease ... • Parvovirus infection ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... fibromyalgia) • Infections ... • Libman-Sacks endocarditis ... lymphopenia, low PLT • Anemia ... common • Antihistone
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... Lady Windermere Syndrome ... : • Syndrome of ... Hematologic malignancy ... Bone Marrow - Anemia
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