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anemia causes hemolysis aiha algorithm autoimmune behcet extravascular intravascular monoclonal oncology paraproteinemias rheumatology signs symptoms table testing workup
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
AIHA (48-70%) Cold ... HA (paroxysmal cold ... hemoglobinuria) • Cold ... Agglutinin Disease ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Autoimmune (AIHA)"Cold ... (e.g. primary cold ... agglutin disease ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... ): SS, SC, SE, Sβ ... Agglutination - Cold ... agglutinins disease ... #workup #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... • AIHA: warm, cold ... #classification ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... Diagnosis #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
matter, spinal cord ... ) Differential Diagnosis ... Oral aphthae : SLE ... • Arthritis: SLE ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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