7 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... #diagnosis #table ... #rheumatology #
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
: The ANA patterns ... (SLE), Sjogren's ... , Interstitial Pulmonary ... #ANA #patterns ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... : • ANCA-associated ... tissue disease ... diseases (i.e. ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
disease, and ocular ... LFT • ESR • ANA ... ) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... searched for when ANA ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... Tracheobronchial disease ... #Syndrome #Rheumatology
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
Antibodies targeting ... had more severe disease ... #AntiNXP2 #Dermatomyositis ... #rheumatology # ... dermatology