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management differential lupus systemic antinuclear activation antinxp2 antinxp2dm autoimmune classification cns dermatology igg4 macrophage mas myopathy myositis neurology patterns phenotypes
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
(SLE) Clinical ... Demyelinating Syndrome ... Cerebrovascular Disease ... #rheumatology # ... cerebritis #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... Syndrome (SS), ... Polymyositis/Dermatomyositis ... , Interstitial Pulmonary ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... , dermatomyositis ... Clinical Features ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... is clinically suspected ... overlap syndromes ... #Antinuclear #autoantibodies ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... MALT Lymphoma • Lung ... #Rheumatology #
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history ... concentration PET-CT ... serum lgE, no autoantibodies ... (antinuclear antibodies ... #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
lung disease Malignancy ... lung disease • ... lung disease • ... Mechanic's hands Autoantibodies ... Myositis #Myopathy #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... • Antibodies targeting ... papules Clinical ... had more severe disease ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammatory lesions-interstitial ... systemic lupus erythematosus ... ) pattern: antibodies ... SLE) • Urinalysis ... #rheumatology #
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