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differential antibodies antinuclear classification activation antineutrophil common cryoglobulinemia cryoglobulins cvid diseases hypogammaglobulinemia immunodeficiency immunology macrophage mas myopathy myositis patterns prs
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Syndrome (SS), ... : Lupus (SLE), Systemic ... Arthritis, Sjögren Syndrome ... , Interstitial Pulmonary ... #patterns #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... lupus erythematosus ... in drug-induced SLE ... cases • Sjögren syndrome ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... , Sjogren syndrome ... lymphoma • Evans' syndrome ... syndrome Arthritis ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... Demyelinating syndromes ... #Lupus #SLE #systemic ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... as systemic lupus ... #rheumatology #
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... 20% Sjögren's syndrome ... DDX: • ANCA (Antineutrophil ... lupus erythematosus ... classification #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... • Systemic lupus ... lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... • Mikulicz syndrome ... #Sjogrens #Syndrome ... #Rheumatology # ... Diagnosis #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... Mucocutaneous lymph node syndrome ... • Behcet syndrome ... • Cogan syndrome ... #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Syndromes - OnePager ... ANCA vasculitis ... Renal Syndromes ... Auto-antibodies: ANCA ... #Renal #Syndromes
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