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differential management antinuclear infections infectiousdiseases lupus vasculitis autoantibodies conditions cvid fungal hematology hiv hypogammaglobulinemia immunodeficiency immunology joint mycoses pain patterns
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... (SLE), Systemic ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... Classification: ... Kidney disease common ... #Diagnosis #Rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Interstitial lung ... , SLE • Pulmonary ... arteritis #Extrarticular ... #differential #diagnosis ... #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... overlap syndromes ... there is no common ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... : • 10%-15% Pulmonary ... MALT Lymphoma • Lung ... #Rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
LFT • ESR • ANA ... ) pattern: antibodies ... SLE) • Urinalysis ... #rheumatology # ... classification
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... Granulomatous lymphocytic interstitial ... lung disease (GLILD ... Chest CT: • Ground-glass ... hemolytic anemia) • Systemic
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
• CT: Halo sign ... papules, pustules, erythematous ... fever, rales, interstitial ... Infections #HIV #AIDS ... #pulmonary #differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
as SLE, atherosclerotic ... Nodosa: • PAN most commonly ... ischemia • Skin: Erythematous ... inflammatory lesions - interstitial ... #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
droppings • Most common ... symptoms • Rheumatologic ... has five major clinical ... yeast • At risk: AIDS ... change in the lungs
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