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differential treatment workup activation anca antineutrophil arthritis conditions cryoglobulinemia cryoglobulins diseases extrarticular hematology igg4 joint laboratory macrophage pain patterns phenotypes
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... lung disease ... lupus erythematosus ... syndrome • IgA ... #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... Vasculitis: • ... Renal-limited vasculitis ... #Antinuclear #Antibody ... #antibodies #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... lupus erythematosus ... lupus erythematosus ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... Diagnosis: Systemic ... , such as systemic ... lupus erythematosus ... , and SLE) • Urinalysis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
) associated vasculitis ... • IgA vasculitis ... • Vasculitis ... lupus erythematosus ... vasculitis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ) • Cutaneous vasculitis ... Vasculitis: • ... #Rheumatology # ... Diagnosis #Management
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Interstitial lung ... , SLE • Pulmonary ... Antiphospholipid-antibody ... Vasculitis (e.g. ... #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic ... , such as SLE, atherosclerotic ... ischemia • Skin: Erythematous ... disease #Vasculitis ... #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Clinical history ... biliary, renal, lung ... concentration PET-CT ... No necrosis, No vasculitis ... #diagnosis #management
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