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antibody nuclear vasculitis classification cytoplasmic dermatology glomerulonephritis management petechiae petechial physicalexam progressive rash rpgn syndrome vasculitides
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... ), Sjogren's Syndrome ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... #Testing #Nuclear ... #differential # ... diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Testing - Nuclear ... pattern: • SLE ... #Patterns #differential ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Purpura Anti-GBM antibodies ... With associated pulmonary ... #diagnosis #algorithm ... #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Diagnosis Algorithm ... Measurement of antinuclear ... • Abdominal ultrasound ... #Diagnosis #Algorithm ... #Causes #dermatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... , INC risk PE, Pulmonary ... #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
, proteinuria, rapidly ... often causes arthritis ... ) pattern: antibodies ... SLE) • Urinalysis ... #diagnosis #rheumatology
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