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differential classification algorithm antibody aortitis cryoglobulinemia cryoglobulins dermatology diseases patterns petechiae petechial physicalexam rash systemic tafro thrombocytopenia types
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... • Sjögren syndrome ... Vasculitis: • ... Renal-limited vasculitis ... #antibodies #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... SLE), Sjogren's ... , Interstitial Pulmonary ... #Antibodies #ANA ... #patterns #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... often causes arthritis ... Vasculitis: + MPO-ANCA ... , and SLE) • Urinalysis ... #rheumatology #
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... ), ANCA associated ... vasculitis (rare ... erythematosus ( ... SLE), Sarcoidosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... • IgA vasculitis ... • Vasculitis ... erythematosus ( ... #vasculitis
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Infection - Vasculitis ... lesions • Severe pain ... - Autoimmune Vasculitis ... (lupus, RA, Sjogren's ... antibodies, antineutrophil
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... diseases, such as SLE ... ischemia • Skin: Erythematous ... often causes arthritis ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... #Syndrome #Rheumatology ... #Diagnosis #Management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
erythematosus ( ... SLE), Sjögren’s ... syndrome, ANCA-associated ... vasculitis - Infectious ... #management #rheumatology
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