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differential classification management algorithm antineutrophil cryoglobulins diseases glomerulonephritis hemoptysis progressive rapidly renal rpgn sjogrens syndrome syndromes treatment types vasculitides
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... - MPO>PR3 - ANCA ... #Antinuclear #Antibody ... #antibodies #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Vasculitis: + MPO-ANCA ... ) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... With associated pulmonary ... -ANCA (C-ANCA): ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... EGPA) • Auto-antibodies ... : ANCA antibody, ... Goodpasture's cause ... • IF staining patterns
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... , such as SLE, atherosclerotic ... often causes arthritis ... + MPO) Cryoglobulinemic ... #Rheumatology
Hemoptysis - Differential Diagnosis Framework Massive Hemoptysis: >150-300 mL in 24h Airway disease: • Bronchitis, Bronchiectasis, Malignancy
in 24h Airway disease ... / Autoimmune: ANCA-Assoc ... vasculitis (GPA ... Goodpasture's, SLE ... #pulmonary #causes
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... : • 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology
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