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ana differential classification erythematosus patterns systemic antibody antineutrophil arthritis autoantibodies cryoglobulinemia cryoglobulins diseases management rheumatoid sjogrens table testing types vasculitides
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... #Antibodies #ANA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... in drug-induced SLE ... #antibodies #diagnosis ... #rheumatology #
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic ... ), Sjogren's Syndrome ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: Systemic rheumatic ... as systemic lupus ... ) pattern: antibodies ... , and SLE) • Urinalysis ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... and fever) and laboratory ... : • ANCA-associated ... vasculitis, rheumatoid
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... is clinically suspected ... overlap syndromes ... erythematosus #diagnosis ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Systemic rheumatic ... as SLE, atherosclerotic ... PMR (Polymyalgia Rheumatica ... gut involvement, abdominal ... #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... ) - Antinuclear ... double-stranded DNA antibodies ... and RF (if clinical ... #Disease #Rheumatoid
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... salivary ducts Clinical ... : • 10%-15% Pulmonary ... #Rheumatology #
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