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differential management erythematosus lupus systemic autoantibodies bcnie bloodculture classification conditions extrarticular fungal infective joint mycoses negative pain patterns polychondritis relapsing
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... ), Sjogren's Syndrome ... , Interstitial Pulmonary ... #Antibodies #ANA
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... is clinically suspected ... overlap syndromes ... erythematosus #diagnosis ... #rheumatology #
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Bacterial or viral infection ... Pulmonary ... • Pulmonary ... #differential #diagnosis ... #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... Syndrome Diagnosis ... ab • RF • Antinuclear ... #Syndrome #Rheumatology
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
antimicrobials, clinical ... Assays for antinuclear ... antibodies, rheumatoid ... antiphospholipid syndrome ... Diseases Fellows
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... dermatomyositis, Sjogren ... syndrome, and mixed ... fibromyalgia) • Infections ... • Libman-Sacks endocarditis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- GI tract: abdominal ... to exclude are infections ... ) pattern: antibodies ... SLE) • Urinalysis ... #rheumatology #
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... Most common • Sjogren ... • Infections ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... has five major clinical ... 3) Abdominal, ... endocarditis Local ... ) #Mycoses #InfectiousDiseases
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