15 results
diagnosis lupus rheumatology erythematosus management systemic table differential druginduced genetics iem immunology inbornerrors metabolism neonatology nicu pediatrics peds acutephasereactants antidsdna
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... Maculopapular rash #C5C9Deficiency ... #Complement #pathophysiology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... calcium-b) • Laboratory ... 90% - Low complement ... versus DIL • Laboratory ... 80% - Low complement
Lab patterns seen in Inborn Errors of Metabolism A table of lab values compiled from UpToDate and
See IEM schema for ... metabolicemergency-pathophysiology-differential-pediatrics-metabolism-algorithm-diagnosis ... Genetics #IEM #Laboratory
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... versus DIL • Laboratory ... 80% - Low complement ... management of SLE
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... ANA level above laboratory ... antibody level above laboratory ... anticoagulant - Low complement ... #Rheumatology #SLE
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Erythematosus (SLE ... HLA-DR3 genes, complement ... self-antigens, activating complement ... Erythematosus #SLE ... #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... differential #diagnosis #algorithm
Lupus - Role of complement and anti-dsDNA for the detection of flares Complement - ↓ Decreased Anti-dsDNA -
Lupus - Role of complement ... detection of flares Complement ... Increased #Lupus #SLE ... #flares #laboratory ... biomarkers #antidsdna #complement
A schema of the pathophysiology of the inborn errors of metabolism, excluding complex storage diseases. Helps
schema of the pathophysiology ... connections and pathophysiology ... See the lab values ... MetabolicEmergency #Genetics #Pathophysiology ... #Diagnosis #Algorithm
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... classical pathway (see ... Complement Activation ... Humoral #Immunity #pathophysiology
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