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diagnosis differential rheumatology lupus pathophysiology signs symptoms acidosis cryoglobulinemia cryoglobulins ddxof elevation em erythematosus fever lactate lactic manifestations msk mucocutaneous
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Erythematosus (SLE ... Manifestations • Immune Complex ... Myopathy (Also caused ... Erythematosus #SLE ... Musculoskeletal #Complications
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... hair follicles -> causes ... inflammation (complex ... Livedo Reticularis, Vasculitis ... signs #symptoms #complications
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • They can cause ... Cryoglobulins Cause ... erythematosus (SLE ... diagnosis #types #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... tracts Immune Complex ... tract, and often causes ... , and SLE) • Urinalysis ... #rheumatology #classification
Serious Bacterial Illness (SBI): 1) UTI and pyelonephritis Most common cause of SBI Accounts for 3-8% of uncharacterized fevers Female
pyelonephritis Most common cause ... presentation Urinalysis: LE ... (particularly complex ... Diagnosis #Peds #EM #Classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... When to Consider Vasculitis ... diseases, such as SLE ... pauci-immune GN Immune Complex ... tract, and often causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... The most common causes ... again we might see ... the patient’s complete ... #typea #typeb #classification
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