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diagnosis signs differential management rheumatology acutelimbischemia agammaglobulinemia amputation barre cli complications disease embolectomy endovascular gbs glomerulonephritis guillain henochscholeinpurpura heparin hsp
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune Complex ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
adhesion of IgA complexes ... Formation of immune complexes ... periumbilical region), nausea ... HenochScholeinPurpura #Pathophysiology ... Diagnosis #Signs #Symptoms
Acute limb ischemia (ALI) Rapid decrease in lower limb blood flow due to acute occlusion of peripheral
limb ischemia (ALI ... The symptoms of ... thromboembolic disease, vasculitis ... pathophysiology: ... chronic & complex
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
antigen-antibody complexes ... Viral replication causes ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms ... #Vasculitis
Pott's Disease in Tuberculosis - Diagnosis and Management Summary Epidemiology: - Typically from TB endemic areas -
extrapulmonary cases ... Clinical Signs/Symptoms ... decreased reflexes Pathophysiology ... Mycobacterium tuberculosis complex ... should be done in ALL
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... inflammation (complex ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... • Progressive symptoms ... pauci-immune GN Immune Complex ... tract, and often causes ... , Elevated AST ALT
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
Inability to produce all ... classes of immunoglobulin ... antibodies) -> Complete ... immunity Signs/Symptoms ... Agammaglobulinemia #XLinked #pathophysiology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Incidence: 1 to 2 cases ... walking to nearly complete ... paralysis of all ... than one after symptom ... the underlying pathophysiology
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