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diagnosis differential workup algorithm aplastic b12 chronic cobalamin common cva cvid deficiency disorders diuresis diuretics excretion fatigue hypogammaglobulinemia immunodeficiency immunology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
family history - Medications ... Risks factor for HIV ... decreased PLT count: CBC ... (CVID, WAS), (neurologic ... changes), high MCV anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Antithyroid medications ... - HIV • Immune ... #oncology #hematology ... #diagnosis #management
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Hypothyroidism • Medication-induced ... • Infectious: HIV ... Paraprotein-associated (POEMS syndrome ... differential #diagnosis #causes ... #neurology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Hepatitis • HIV ... Pulmonary Disease Neurologic ... Chronic Fatigue Syndrome
How do you work up an ischemic CVA? A) Initial Evaluation • ABCs • IV access, monitor
Evaluation • ABCs • IV ... Finger glucose • Medication ... ) Other: • CBC ... workup #diagnosis #checklist ... #neurology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... , HIV) • Glucocorticoid ... hypogammaglobulinemia #immunology #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... gastric acidity, medications ... • Labs: - CBC ... consider IM or IV ... Deficiency #diagnosis #management
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
irrigation • Management ... Kidney stones caused ... Association class IV ... Excretion #Diuresis #Nephrology ... #Pharmacology #Medications
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