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diagnosis causes coagulation differential abnormal algorithm disease nonalcoholic prolonged syndrome treatment activation aih autoimmune blood cirrhosis dic diet disorders disseminated
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
and/or aPTT Prolonged ... to one factor e.g ... and aPTT 1. ... inhibitory drugs e.g ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
and aPTT If the ... PT and the aPTT ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... Study #diagnosis #hematology ... #hematology #laboratory
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
patients with NAFLD ... or liver disease ... fibrosis; FIB-4 ... algorithm #Referral #Management ... #Hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
selected cases: INR/PT ... , aPTT(liver disease ... function test, ANA (e.g ... bypass), LFT (liver ... Causes #Workup #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Hemophilia - Diagnosis and ... mixing study (aPTT ... mild cases) • PT ... hemophilia type (e.g ... #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... S Pathophysiology ... DIC • Severe Liver ... causes #treatment #management ... #hematology
Non-Alcoholic Fatty Liver Disease (NAFLD) - Diagnosis Algorithm Low Suspicion: ≤ 1 feature of
Non-Alcoholic Fatty Liver ... Disease (NAFLD) ... cirrhosis AND ... FIB < 1.3 ... Diagnosis #Algorithm #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
inflammation (eg ... been reported (eg ... of Hepatitis (eg ... Histology Findings (eg ... #Hepatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... #Hematology #Rheumatology
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